Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

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Double membrane vesicles (DMV) Vehicle Parts are used as replication organelles by several RNA viruses.Applying proteomics and lipidomics, Tabata and Prasad et al.find that two cellular acyltransferases (AGPAT1/2), responsible for synthesis of Yarrow Flowers phosphatidic acid, play a role in the DMV-biogenesis of HCV and SARS-CoV-2, highlighting a common biogenesis mechanism for evolutionary distant positive-strand RNA viruses.